Figure 2: Kinetic uptake characteristics of a linear and cyclic form of TAT. | Nature Communications

Figure 2: Kinetic uptake characteristics of a linear and cyclic form of TAT.

From: Backbone rigidity and static presentation of guanidinium groups increases cellular uptake of arginine-rich cell-penetrating peptides

Figure 2

(a) Confocal optical sections of timelapse movies (Supplementary Movie 1) show the uptake of fluorescently labelled linear and cyclic TAT in the presence of serum-free medium. Scalebar, 10 μm. (b) Mean fluorescence intensity of fluorescein-labelled linear (triangles) and cyclic (circles) TAT inside the nucleus was monitored over 60 min at a frame rate of one image every 79 s. (c) Radii of gyration (circles) and guanidinium group distances (squares) derived from the molecular dynamics simulations.

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