Figure 2: Proposed mechanism for reaction between 1 and 5 to produce uracil and lumazine derivatives. | Nature Communications

Figure 2: Proposed mechanism for reaction between 1 and 5 to produce uracil and lumazine derivatives.

From: Stabilizing short-lived Schiff base derivatives of 5-aminouracils that activate mucosal-associated invariant T cells

Figure 2

These reactions are reversible in water, but dehydrative cyclization drives formation of thermodynamically more stable aromatic lumazine derivatives 4. Polar aprotic solvents may facilitate kinetic control of these equilibria and enable trans-3 to persist in solution.

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