Table 1 GO analyses of APA genes between consecutive time points after VSV infection.
From: The role of alternative polyadenylation in the antiviral innate immune response
GO terms | P -value | |
|---|---|---|
0–2 h | Enzyme-linked receptor protein signalling pathway | 8.64 × 10−5 |
Protein kinase cascade | 3.13 × 10−3 | |
Response to endogenous stimulus | 7.32 × 10−3 | |
Activation of MAPK activity | 0.0149 | |
Regulation of JUN kinase activity | 0.0184 | |
Positive regulation of signal transduction | 0.0253 | |
2–4 h | Phosphorylation | 2.49 × 10−4 |
Regulation of transcription | 3.38 × 10−4 | |
Positive regulation of signal transduction | 3.40 × 10−4 | |
JAK-STAT cascade | 5.57 × 10−3 | |
Response to dsRNA | 0.0198 | |
Endocytosis | 0.025 | |
4–8 h | Negative regulation of apoptosis | 1.64 × 10−4 |
Protein localization | 7.46 × 10−4 | |
Inflammatory response | 3.50 × 10−3 | |
Defence response | 5.27 × 10−3 | |
Cell surface receptor-linked signal transduction | 6.35 × 10−3 | |
Response to virus | 0.034 | |
Endosome transport | 0.037 | |
Immune response | 0.0555 | |
8–16 h | Protein transport | 3.60 × 10−5 |
Protein localization | 5.42 × 10−5 | |
Regulation of cell death | 3.52 × 10−4 | |
Immune response | 4.32 × 10−4 | |
Inflammatory response | 1.28 × 10−3 | |
Endocytosis | 5.18 × 10−3 | |
Response to virus | 5.25 × 10−3 | |
Positive regulation of T-cell proliferation | 0.0116 | |
16–24 h | Protein transport | 4.85 × 10−7 |
Establishment of protein localization | 6.44 × 10−7 | |
Regulation of phosphate metabolic process | 4.94 × 10−6 | |
Regulation of phosphorylation | 1.31 × 10−5 | |
Regulation of kinase activity | 2.13 × 10−5 | |
Cell death | 5.47 × 10−5 | |
Apoptosis | 9.92 × 10−5 | |
Endocytosis | 6.50 × 10−3 |
