Figure 4: Functional similarity between mouse and zebrafish synaptic proteomes.

(a) Fraction of mouse (red) and zebrafish (yellow) synaptic proteins annotated to IPA cell location categories. (b) Fraction of mouse (red) and zebrafish (yellow) synaptic proteins annotated to IPA molecular function categories. (c) Overlap between Biological Process and Molecular Function GO-slim terms⁶⁸ and PANTHER Protein Classes⁶⁹ enriched in mouse and zebrafish. Top row shows data for synaptosomes and bottom row for PSD proteomes. The exact percentage of overlap is indicated. (d) Cumulative frequency distribution plots of individual protein innovation index (number of unique domain types per protein) for each proteome in mouse. Statistically significant comparisons between pairs of distributions (two-tailed Kolmogorov–Smirnov test applied to distributions) are shown at the legend. ***P<0.001, **P<0.01, *P<0.05; nonsignificant comparisons are not shown. (e) Cumulative frequency distribution plots of individual protein innovation index (number of unique domain types per protein) for each proteome in zebrafish. Statistically significant comparisons between pairs of distributions (two-tailed Kolmogorov–Smirnov test applied to distributions) are shown at the legend. ***P<0.001, **P<0.01, *P<0.05; nonsignificant comparisons are not shown.