Table 2 Functional annotation of mammalian PSD proteins absent from the zebrafish synapse.

From: Evolution of complexity in the zebrafish synapse proteome

 

Human

Rat

Mouse

 

Fold change*

P value #

Fold change*

P value #

Fold change*

P value #

Related to vesicle-mediated protein traffic and localization

 Regulation of vesicle-mediated transport (GO:0060627)

3.3

1.3E−04

3.4

1.7E−03

2.3

3.0E−04

 Vesicle-mediated transport (GO:0016192)

2.9

5.8E−10

2.4

7.1E−03

2.2

1.7E−12

 Cytoplasmic transport (GO:0016482)

2.9

5.0E−06

2.6

1.9E−02

2.0

1.2E−04

 Establishment of protein localization (GO:0045184)

2.9

1.2E−12

2.2

1.7E−03

2.2

2.5E−15

 Protein transport (GO:0015031)

2.8

2.7E−10

2.3

4.1E−03

2.2

3.5E−14

 Intracellular transport (GO:0046907)

2.7

9.9E−10

2.5

6.3E−06

2.2

4.0E−15

 Endosome (GO:0005768)

2.2

3.3E−02

2.5

3.2E−03

2.3

6.8E−10

Related to protein location at plasma membrane

 Extrinsic component cytoplasmic side of plasma membrane (GO:0031234)

5.8

2.8E−04

5.9

5.2E−03

3.5

9.4E−04

 Extrinsic component of plasma membrane (GO:0019897)

5.1

1.1E−04

5.3

8.1E−04

3.3

6.5E−05

 Cytoplasmic side of plasma membrane (GO:0009898)

4.5

5.3E−04

6.1

2.6E−06

3.7

1.1E−07

 Cytoplasmic side of membrane (GO:0098562)

4.2

1.4E−03

5.7

7.7E−06

3.5

2.1E−07

 Extrinsic component of membrane (GO:0019898)

3.3

6.3E−03

3.6

1.1E−02

2.5

2.8E−04

Related to actin filaments organization

      

 Regulation of actin filament length (GO:0030832)

4.6

2.8E−03

4.8

1.7E−02

2.9

9.7E−03

 Actin cytoskeleton organization (GO:0030036)

4.0

1.8E−08

3.3

3.7E−03

2.4

7.9E−06

 Actin filament-based process (GO:0030029)

4.0

1.3E−09

3.4

5.9E−04

2.6

3.8E−08

 Regulation of cytoskeleton organization (GO:0051493)

3.4

8.1E−06

3.2

3.9E−03

2.7

3.0E−09

Related to cation transport

 Regulation of cation transmembrane transport (GO:1904062)

4.4

1.1E−04

4.6

1.2E−03

2.7

2.7E−03

 Regulation of metal ion transport (GO:0010959)

3.0

2.3E−02

3.4

1.7E−02

2.2

4.2E−03

 Transmembrane transporter complex (GO:1902495)

3.0

2.8E−02

3.4

1.1E−02

2.7

5.0E−06

 Transporter complex (GO:1990351)

2.9

3.8E−02

3.3

1.5E−02

2.7

1.2E−06

Related to cell junction

 Adherens junction (GO:0005912)

3.9

1.8E−09

3.3

2.1E−04

2.2

1.3E−04

 Cell–substrate junction (GO:0030055)

3.9

1.1E−07

3.7

3.8E−05

2.0

1.7E−02

 Anchoring junction (GO:0070161)

3.7

6.3E−09

3.3

1.3E−04

2.2

9.8E−05

 Cell junction (GO:0030054)

2.9

2.0E−13

3.0

3.0E−12

2.4

2.1E−22

  1. GO, Gene Ontology; PSD, postsynaptic density.
  2. *Fold enrichment of observed proteins per GO term.