Figure 6: Schematic model for the allosteric regulation of PMP binding by farnesylation. | Nature Communications

Figure 6: Schematic model for the allosteric regulation of PMP binding by farnesylation.

From: Allosteric modulation of peroxisomal membrane protein recognition by farnesylation of the peroxisomal import receptor PEX19

Figure 6

In case of non-farnesylated PEX19 CTD, the helix α1 is flexible in solution and only loosely attached to the helical core domain of the PEX19 CTD, while the lid adopts an open conformation. Farnesylation induces a specific, rigid arrangement of these two structural elements, thus forming a hydrophobic cavity, which then forms a high-affinity binding site for PMPs.

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