Figure 8: The model for exocytotic granules-coupled actin framework formation and subsequent actin coating. | Nature Communications

Figure 8: The model for exocytotic granules-coupled actin framework formation and subsequent actin coating.

From: Zyxin regulates endothelial von Willebrand factor secretion by reorganizing actin filaments around exocytic granules

Figure 8

Upon stimulation, the pre-existing filaments were reorganized to form the actin frameworks around exocytic granules, limiting the granules’ movement and promoting them close to the plasma membrane. Subsequently, actin monomers are recruited from the cytosol and form coat structures around granules within the actin frameworks upon fusion. Cells may use such a synergetic strategy to promote exocytosis effectively and precisely.

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