Figure 6: A model of the role of upd3-Stat92E signalling in the M. marinum-infected phagocyte.
From: Regulation of phagocyte triglyceride by a STAT-ATG2 pathway controls mycobacterial infection
Upon infection, haemocytes secrete upd3, which activates the JAK–STAT pathway by signalling back to haemocytes. Upon activation of JAK–STAT, Atg2 expression is reduced, large and irregular LDs are formed, and the bacteria survive and proliferate within the immune cell. However, if the JAK–STAT pathway is inhibited, Atg2 expression is increased and ATG2 protein is found surrounding LDs and bacteria (red dots). The LDs maintain small and circular structures and the bacteria are less able to survive or replicate.
