Figure 8: Control of EphA2 trafficking during cell scattering. | Nature Communications

Figure 8: Control of EphA2 trafficking during cell scattering.

From: Phosphorylation of Rab-coupling protein by LMTK3 controls Rab14-dependent EphA2 trafficking to promote cell:cell repulsion

Figure 8

(a) EphA2 is constitutively internalized and returned to the plasma membrane without transit through RCP-positive endosomes, and RCP is associated primarily with Rab11. (b) Addition of HGF triggers LMTK3-dependent phosphorylation of RCP at Ser435 which favours RCP’s association with Rab14. In parallel with this, HGF promotes Akt-mediated phosphorylation of EphA2 at Ser897. Both of these phosphorylation events are necessary to promote diversion of EphA2 from a rapid recycling pathway to a slower one which transits through RCP/Rab14-positive endosomes, and to enable EphA2-dependent cell:cell repulsion and scattering.

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