Figure 4: SWI/SNF subunit deletion results in downregulation of specific developmental targets.
From: The SWI/SNF chromatin remodelling complex is required for maintenance of lineage specific enhancers
(a). Number of TF motif matches within lost enhancers relative to an expectation based on numbers in stable enhancers. The strongest enrichment/depletion is seen for motifs similar to AP-1, ETS and CTCF motifs, which are highlighted. (b). Correlation of nearby gene expression (5–100 kb) changes with H3K27ac signal changes at enhancers upon Smarcb1 or Smarca4 deletion. The boxes indicate first, second, and third quartiles, and whiskers show 1.5 × interquartile range below and above the first and third quartile, respectively. Two sided t-test P values are shown. (c) Selected GO terms enriched in downregulated genes. Hypergeometric test P values are shown after Benjamini–Hochberg correction for multiple-hypothesis testing.
