Figure 1: Ep3 blockade represses recruitment of Ly6Clow Mos/Mps in peritonitis in mice. | Nature Communications

Figure 1: Ep3 blockade represses recruitment of Ly6Clow Mos/Mps in peritonitis in mice.

From: Activation of E-prostanoid 3 receptor in macrophages facilitates cardiac healing after myocardial infarction

Figure 1

(a) Gating strategy for peritoneal Ly6Chigh and Ly6Clow Mos/Mps in zymosan-induced peritonitis in mice. (b) Relative mRNA levels of the PG E2 receptors (Ep1–4) in peritoneal Ly6Chigh and Ly6Clow Mos/Mps; data represent mean±s.e.m. *P<0.05 versus Ly6ChighMos/Mps (unpaired two-tailed t-test); n=5. (c–e) Effect of administration of different PGE2 receptor blockers on recruitment of total Mos/Mps (c), Ly6Chigh (d), and Ly6Clow (e) Mos/Mps at 48 h and 96 h after a zymosan challenge in mice. Data represent mean±s.e.m. *P<0.05 versus control(unpaired two-tailed t-test); n=5–6. SC-51322, Ep1 inhibitor; AH6809, Ep2 inhibitor; L-798106, Ep3 inhibitor; L-161982, Ep4 inhibitor. (f,g) Effect of different PGE2 receptor blockers on expression of anti-inflammatory (f) and pro-inflammatory (g) markers in peritoneal Mos/Mps collected 48 h after zymosan treatment. Data represent mean±s.e.m. *P<0.05 versus control (unpaired two-tailed t-test); n=4.

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