Figure 2: Ep3 deletion suppresses Ly6Clow Mo/Mp infiltration in peritonitis in mice. | Nature Communications

Figure 2: Ep3 deletion suppresses Ly6Clow Mo/Mp infiltration in peritonitis in mice.

From: Activation of E-prostanoid 3 receptor in macrophages facilitates cardiac healing after myocardial infarction

Figure 2

(a) Genotyping of Ep3F/F;LysMCre mice. Microsomal epoxide hydrolase (mEH) was used as quality control for extracted DNA from mouse tail biopsy. (b) Ep3 receptor expression levels in peritoneal Mps from Ep3F/F;LysMCre and Ep3F/Fmice. Data represent mean±s.e.m. **P<0.01 versus Ep3F/F(unpaired two-tailed t-test); n=10. (c–e) Effect of Ep3 deletion on recruitment of total Mos/Mps (c), Ly6Chigh (d), and Ly6Clow subtype (e) Mos/Mps 48 and 96 h after a zymosan challenge in mice. Data represent mean±s.e.m. *P<0.05 versus Ep3F/F (unpaired two-tailed t-test); n=5–7. (f,g) Effect of Ep3 deficiency on expression of proinflammatory (f) and reparative angiogenic markers (g) in peritoneal Mos/Mps collected 48 h after zymosan treatment. Data represent mean±s.e.m. *P<0.05 versus Ep3F/F (unpaired two-tailed t-test); n=10–11.

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