Figure 6: Ep3 overexpression in Mos/Mps improves cardiac recovery after MI in mice. | Nature Communications

Figure 6: Ep3 overexpression in Mos/Mps improves cardiac recovery after MI in mice.

From: Activation of E-prostanoid 3 receptor in macrophages facilitates cardiac healing after myocardial infarction

Figure 6

(a–c) Effect of Ep3 overexpression on recruitment of total Mos/Mps (c), Ly6Chigh, (d) and Ly6Clow Mos/Mps in injured hearts mice after MI. Data represent mean±s.e.m. *P<0.05 versus WT (unpaired two-tailed t-test); n=5–7. (d) Representative immunostainings of CD31 (red) and PCNA (yellow) in peri-infarct zones of hearts from WT, Mp-Ep3Tg-C and Mp-Ep3Tg-E mice at day 14 post-MI. The solid box outlines the region enlarged to the right; yellow arrow, CD31+/PCNA+ cell. Scale bar, 20 μm. (e,f) Quantitation of CD31+ areas (e) and PCNA+CD31+ cells (f) in injured hearts, as shown in d. Data represent mean±s.e.m. *P<0.05 versus WT, #P<0.05 as indicated(unpaired two-tailed t-test); n=6. (g) Cardiac function of WT, Mp-Ep3Tg-C and Mp-Ep3Tg-E mice at day 14 after MI. Data represent mean±s.e.m. *P<0.05 versus WT, #P<0.05 as indicated (unpaired two-tailed t-test); n=7–8.

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