Figure 5: Activating mutations in Parkin show higher levels of mitophagy.
From: Structure-guided mutagenesis reveals a hierarchical mechanism of Parkin activation
(a) Mitophagy was examined using a FACS-based analysis of mitochondrially targeted mKeima (mt-mKeima). Representative FACS data of mt-mKeima expressing WT or hyperactive Parkin mutants untreated or treated with CCCP for 4 h from two experiments. (b) Quantification of average percentage of mitophagy. **P<0.001; ***P<0.0001; n.s., nonsignificant (one-way ANOVA with Tukey’s post test).
