Figure 6: Activating mutations can rescue defects in mitophagy.
From: Structure-guided mutagenesis reveals a hierarchical mechanism of Parkin activation
(a,b) Representative FACS data of mt-mKeima U2OS cells expressing WT or Parkin mutants untreated or treated with 20 μM CCCP for 4 h. (c,d) Quantification of average percentage of mitophagy from three independent experiments. Vertical bars represent s.e.m.. For statistical analysis, a one-way ANOVA with Tukey’s post test was performed. ***P<0.0001; n.s., non significant.
