Figure 5: smg-1 overexpression increases lifespan. | Nature Communications

Figure 5: smg-1 overexpression increases lifespan.

From: RNA surveillance via nonsense-mediated mRNA decay is crucial for longevity in daf-2/insulin/IGF-1 mutant C. elegans

Figure 5

(a) Images of SMG-2::GFP-expressing worms (scale bar, 100 μm) (arrow: neurons, arrowhead: intestine, asterisk: muscles). (b,c) The smg-2::gfp transgene restored longevity in smg-2(−); daf-2(−) mutants (b), and in smg-2(−) animals (c). (d) The smg-2::gfp transgene had no significant effect on the lifespan of control (odr-1p::rfp) worms. (e) Three independent smg-1 transgenic lines increased the lifespan of control (odr-1p::rfp) worms. smg-1::gfp line 1 increased lifespan in one out of three trials. See Supplementary Data 1 for statistical analysis and additional repeats.

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