Figure 2: Structural comparison of NS5 proteins from ZIKV and two other flaviviruses. | Nature Communications

Figure 2: Structural comparison of NS5 proteins from ZIKV and two other flaviviruses.

From: The structure of Zika virus NS5 reveals a conserved domain conformation

Figure 2

Structural superposition of ZIKV NS5 with (a) JEV NS5 (PDB 4K6M) and (b) DENV3 NS5 (PDB 4V0Q). Alignment of the RdRp domains of ZIKV NS5 and DENV3 NS5 leads to a ∼100° change in orientation between the MTase and RdRp domains. The NTP entrance and RNA exit sites are labelled. (c–e) The MTase–RdRp domain interactions of (c) ZIKV NS5, (d) JEV NS5 and (e) DENV3 NS5.

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