Figure 1: Development of KDM4A cyclic peptide inhibitors.
From: Highly selective inhibition of histone demethylases by de novo macrocyclic peptides
Cyclic peptide binders of KDM4A were selected using the RaPID system (Supplementary Fig. 1). The hit peptide sequences (CP1–CP5) were synthesized and further tested in enzymatic assays. Peptides were cyclized by a thioether formation.
