Figure 4: Crystallography and mass spectrometry guided modifications of CP2.
From: Highly selective inhibition of histone demethylases by de novo macrocyclic peptides
(a) Sites of modifications were made based on the crystal structure and MS degradation analysis. (b) MS analysis of degradation fragments of CP2(T13Z) observed on incubation with cell lysate. Cleavage sites are indicated as blue lines.
