Figure 7: Schematic model representing how CD47 transcriptional expression is regulated during inflammation in cancer. | Nature Communications

Figure 7: Schematic model representing how CD47 transcriptional expression is regulated during inflammation in cancer.

From: A CD47-associated super-enhancer links pro-inflammatory signalling to CD47 upregulation in breast cancer

Figure 7

The TNF pathway activates the translocation to the nucleus of NFKB1. Upstream unknown factors, bind to closed DNA, making SE constituents accessible to NFKB1 binding, which in turn activate SEs and recruit BRD4 to these SEs promoting the interaction between the distal SE(s) and the promoter of the gene to initiate transcription. Dotted lines indicate indirect interactions while solid lines indicate direct interactions.

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