Figure 5: ChREBP overexpression partially restores hepatic lipogenesis.
From: Regulation of hepatic lipogenesis by the zinc finger protein Zbtb20
3-4 month-old male control or LZB20KO mice were i.v. injected with ChREBP-β-expressing adenoviruses (Ad-ChREBP) or Ad-GFP as control. One week later, gene expression and phenotypes were analysed. n=5 per group. (a) Partial restoration of glycolytic and lipogenic gene expression in LZB20KO liver by ChREBP-β overexpression. (b) ChREBP-β protein was still undetected in ChREBP-β-overexpressed liver from by western blot. NS, nonspecific band. (c,d) ChREBP-β overexpression partially restored lipid and glucose metabolism in the plasma (c) and liver (d). Data are represented as mean±s.e.m. *P<0.05; **P<0.01 versus indicated groups (Student’s t-test).
