Figure 2: Duration of activity of anti-VEGF molecules in the rabbit retinal leakage model.
From: Long-acting protein drugs for the treatment of ocular diseases
Two days before fluorescein angiography, retinal vessel permeability was induced by an intravitreal injection of 10 pmol per eye hVEGF-A165. hVEGF-induced fluorescein leakage was measured in six to eight rabbit eyes for each anti-VEGF molecule and compared with control eyes that received intravitreal hVEGF but no anti-VEGF molecule. Each data point represents the average inhibition of vascular leakage compared with controls. LAVA1 inhibited fluorescein leakage when administered up to 28 days prior the hVEGF challenge (30 days before fluorescein angiography), whereas equimolar doses of ranibizumab, bevacizumab, aflibercept, brolucizumab or DARPin-PEGOL did not substantially inhibit fluorescein leakage when administered 18–21 days before the hVEGF challenge (20–23 days before fluorescein angiography). Data shown are from several independent studies.
