Figure 3: Efficacy of NVS0 and LAVA1 in the cynomolgus monkey laser-CNV model.

CNV lesions were induced 4–9 months before dosing. Representative images of cynomolgus monkey eyes injected with NVS0 or LAVA1. The fundus images are shown as negatives (black and white reversed) to highlight the vascular leakage of fluorescein during fluorescein angiography. Each eye received four laser burns producing neovascular tufts (CNV) that appear as dark spots in the images; the darkness corresponds to the degree of vascular leakage from the lesions. The asterisks ‘*’ in the fundus images correspond to the lesion from which retinal thickness was measured by optical coherence tomography (OCT). Total retinal thickness (values shown in the bottom of each OCT scan) was measured at the center of the lesion using calipers provided in the Spectralis software as the distance between the inner limiting membrane and retinal pigment epithelium (RPE) as shown by the arrow heads in the OCT of 362081 left eye. Both NVS0 and LAVA1 markedly reduced CNV-induced retinal oedema within 4 weeks. The plot shows the number of grade IV lesions at the time of dosing, 1 week and 4 weeks post dosing with NVS0 or LAVA1. Both NVS0 and LAVA1 reduced the number of grade IV lesions and retinal oedema within 4 weeks of injection.