Figure 2: Cluster analysis based on HOX-encoded transcripts in human SFs from different locations. | Nature Communications

Figure 2: Cluster analysis based on HOX-encoded transcripts in human SFs from different locations.

From: Epigenetically-driven anatomical diversity of synovial fibroblasts guides joint-specific fibroblast functions

Figure 2

Cluster analysis of RNA sequencing data using (a) protein-coding RNA, (b) long noncoding RNA and (c) microRNA transcripts encoded in HOX loci clearly discriminated between SFs of different anatomical locations (n=21). Heatmaps display Z-scores of normalized read counts. Genes encoded within HOX loci were identified using the HOX gene annotation in GRCh38.p2, Ensembl Release 80 (May 2015). Only transcripts expressed above the threshold level were used in the cluster analysis. HA, hand; KN, knee; Nor, non-arthritic joint pain; OA, osteoarthritis; RA, rheumatoid arthritis; SH, shoulder.

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