Figure 6: MetaCore pathway analysis of transcriptomes from different joints. | Nature Communications

Figure 6: MetaCore pathway analysis of transcriptomes from different joints.

From: Epigenetically-driven anatomical diversity of synovial fibroblasts guides joint-specific fibroblast functions

Figure 6

Process Network Enrichment analysis of RNA sequencing data (n=21) between joint locations (knee versus hand, knee versus shoulder and hand versus shoulder) and upper versus lower extremities using MetaCore from Thomson Reuters (see also Supplementary Data 3). (a–d) Heatmaps of the enriched transcripts for selected arthritis-relevant process networks among all significantly enriched process networks between joints are shown. Red arrows point to the transcripts further studied or discussed in the paper. Heatmaps display Z-scores of normalized read counts.

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