Figure 1: Glyoxalase I pathway and glyoxalase I-mimic reaction design. | Nature Communications

Figure 1: Glyoxalase I pathway and glyoxalase I-mimic reaction design.

From: Biomimetic catalytic transformation of toxic α-oxoaldehydes to high-value chiral α-hydroxythioesters using artificial glyoxalase I

Figure 1

(a) Detoxification of methylglyoxal via enantioselective isomerization catalysed by glyoxalase I. M=Zn for the eukaryotic glyoxalase I such as human and yeast; M=Ni for the prokaryotic glyoxalase I such as the bacteria Escherichia coli and Pseudomonas aeruginosa. (b) Plausible working hypothesis for the enantioselective isomerization of hemithioacetals catalysed by artificial glyoxalase I.

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