Figure 2: POT1C—TPP1(PBD) interactions.
From: Structural and functional analysis of the human POT1-TPP1 telomeric complex
(a) Contacts between the POT1C OB-fold (blue) and the α3 and α4 helices of TPP1(PBD) (green); the disease mutation L343F is shown in stick. (b) Extensive interactions between the POT1C-HJR (red) and the leucine rich α1 of TPP1(PBD) (green) are shown. The P446Q and P475L mutations are highlighted with a box. (c) Contacts of the TPP1 helix α2 at the interface of the OB-fold and HJR of POT1C are shown. (d) The R477T, A532P and I532F disease mutations form part of the HJR of POT1C. The position of these amino acids with respect to the nearest TPP1 structural element (α1–green colour) are shown. (e) Extensive interactions between the POT1C OB-fold (blue) and helices α3 and α4 of TPP1(PBD) (green) are shown. The disease mutations C591W and Q623H are highlighted with a box.
