Table 1 Association of the *IGHV4-61**02 allele with RHD susceptibility by ancestry and country.

Grouping	Population	Subpopn	Subgroup	Cases	Controls	Effective	Minor allele freq.		Method	λ	OR (95% CI)	P
				N	N	N	Cases	Controls
Ancestry	Melanesian	All	All	607	1229	1625	0.31	0.26	LMM	1.06	1.37 (1.19–1.57)	1.2 × 10 ^{− 5}
		iTaukei	All	307	553	790	0.32	0.24	LMM	1.02	1.34 (1.07–1.67)	0.011
			Matched	296	296	592	0.32	0.25	LMM	1.01	1.49 (1.15–1.94)	0.003
									LR	1.01	1.51 (1.15–1.98)	0.0024
		Kanak	All	280	154	397	0.31	0.22	LMM	1.03	1.80 (1.30–2.49)	0.00039
			Matched	153	153	306	0.29	0.19	LMM	1.09	1.77 (1.22–2.58)	0.0028
									LR	1.07	1.80 (1.21–2.69)	0.0028
	Polynesian	All	All	160	233	379	0.27	0.21	LMM	1.02	1.53 (1.12–2.10)	0.0072
		Samoan	All	61	74	134	0.32	0.18	LMM	0.99	2.07 (1.23–3.50)	0.0062
			Matched	55	55	110	0.35	0.18	LMM	0.99	2.16 (1.25–3.75)	0.0061
									LR	1.04	2.24 (1.21–4.15)	0.0066
	Fijian Indian	All	All	168	151	318	0.18	0.12	LMM	1	1.91 (1.18–3.10)	0.0082
		All	Matched	142	142	284	0.18	0.11	LMM	1	1.99 (1.18–3.36)	0.0096
									LR	1.00	2.02 (1.18–3.49)	0.0092
	Mixed and other	All	All	71	236	218	0.26	0.17	LMM	1.02	1.54 (0.97–2.46)	0.069
Country	Fiji Islands	All	All	532	751	1245	0.27	0.22	LMM	1.02	1.39 (1.16–1.67)	0.00043
	New Caledonia	All	All	422	362	779	0.28	0.18	LMM	1.02	1.57 (1.25–1.97)	8.6 × 10⁻⁵
	Samoa	All	All	61	75	135	0.32	0.18	LMM	0.99	2.10 (1.25–3.54)	0.0054

CI, confidence interval; freq., frequency; LMM, linear mixed model; LR, logistic regression; OR, odds ratio; RHD, rheumatic heart disease; Subpopn, subpopulation.
Lines highlighted in bold refer to the initial discovery and replication analyses, while other lines refer to subsequent sensitivity analyses. The genomic control factor (λ) was calculated from a genome-wide analysis using the analytical method indicated.

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