Figure 3: Structure of hEXOG–dsDNA complex.
From: A domain in human EXOG converts apoptotic endonuclease to DNA-repair exonuclease
(a) The complex has dsDNA in each active site. (b) Asymmetry of hEXOG upon DNA binding. Superposition of the apo enzyme and in a DNA complex in the open (left) and closed (right) monomer shows wing domain movements. (c) DNA interactions with the ‘open’ Wing domain. (d) The bound dsDNA (magenta and grey) partially transition to A-form from an ideal B-form (green). (e) DNA interactions with the ‘closed’ Wing domain.
