Figure 7: Radiation protection and mitigation by TPP-IOA and TPP-ISA.
From: A mitochondria-targeted inhibitor of cytochrome c peroxidase mitigates radiation-induced death
C57BL/6NTac female mice were exposed to total body irradiation to a dose of 9.25 Gy using a cesium source (n=31–35 mice per group) (a) or a linear accelerator (n=10–23 mice per group) (b). (a) The mice were irradiated and injected i.p. with TPP-IOA or TPP-ISA (5 mg per kg body weight in 100 μl of water containing 25% ethanol) 10 min after irradiation. Mice exposed to: total body irradiation at the dose of 9.25 Gy only (black circles); to total body irradiation at the dose of 9.25 Gy and injected with TPP-ISA (5 mg per kg body weight) 10 min (blue triangles) or TPP-IOA (5 mg per kg body weight) 10 min (red squares) thereafter. P<0.0001 (a two-sided log-rank test)—TPP-IOA or TPP-ISA injected and exposed to total body irradiation mice versus mice exposed to total body irradiation only. (b) The mice were injected i.p. with TPP-IOA (5 mg per kg body weight in 100 μl of water containing 25% ethanol) at 1 h or 10 min before irradiation or 10 min, 5 or 24 h after irradiation. Mice exposed to: total body irradiation at the dose of 9.25 Gy only (black circles); to total body irradiation at the dose of 9.25 Gy and injected with TPP-IOA (5 mg per kg body weight) 10 min (blue circles), 5 h (blue triangles) and 24 h (blue squares) thereafter. Mice injected with TPP-IOA (5 mg per kg body weight) 10 min (red squares) and 1 h (red triangles) before total body irradiation (9.25 Gy). For assessments of significance see Table 1.
