Table 1 TPP-IOA and TPP-ISA increase survival of mice following irradiation.

From: A mitochondria-targeted inhibitor of cytochrome c peroxidase mitigates radiation-induced death

Treatment group

Overall survival (52 days)

Survival over first 20 days

N

 

Median survival (95% confidence interval)

P*

Median survival (95% confidence interval)

P*

 

9.25 Gy

13 (11, 14)

 

13 (11, 14)

 

22

TPP-IOA 5 mg per kg body weight, 1 h before 9.25 Gy

— (12, —)

0.0230

— (12, —)

0.0230

10

TPP-IOA 5 mg per kg body weight, 10 min before 9.25 Gy

— (18, —)

0.0009

— (18, —)

0.0009

10

TPP-IOA 5 mg per kg body weight, 10 min after 9.25 Gy

— (—, —)

<0.00010.4567†

— (—, —)

<0.0001

23

TPP-IOA 5 mg per kg body weight, hr after 9.25 Gy

— (17, —)

0.0030

— (17, —)

0.0030

10

TPP-IOA 5 mg per kg body weight, 24 h after 9.25 Gy

18 (13, —)

0.0416

18 (13, —)

0.0416

10

TPP-IOA 2.5 mg per kg body weight, 10 min after 9.25 Gy

17 (14, —)

0.0525

17 (14, —)

0.0525

10

TPP-ISA 5.0 mg per kg body weight 10 min after 9.25 Gy

— (13, —)

0.0114

— (13, —)

0.0114

22

  1. The two-sided log-rank test was used to examine the differences between irradiated mice with or without treatment with TPP-ISA or TPP-IOA.
  2. Mice were irradiated to 9.25 Gy using a Varian TrueBeam linear accelerator (Varian Medical Systems) and injected i.p. with either TPP-ISA or TPP-IOA (2.5 or 5 mg per kg body weight in 100 μl of water containing 25% ethanol) at 1 h or 10 min before irradiation or 10 min, 5 or 24 h after irradiation.
  3. *TPP-IOA and TPP-ISA versus irradiated mice.
  4. †TPP-IOA (5 mg per kg body weight 10 min after irradiation) versus TPP-ISA (5 mg per kg body weight 10 min after irradiation).
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