Figure 1: Map of TERT and CLPTM1L region.

Recombination hotspots in the CEU population (red line), as well as 1000G combined recombination rate (blue line) across the TERT/CLPTM1L region are shown relative to the CLPTM1L and TERT genes, as well as the grouping of ten highly correlated sequence variants strongly associated with risk of pancreatic, testicular, and lung cancers in the region closest to CLPTM1L. (a) Chromatin interaction analysis paired-end (ChIA-PET) sequencing data from the K562 chronic myeloid leukaemia cell line using an antibody against RNA polymerase II generated by the ENCODE project (https://www.encodeproject.org/) is shown. For each of the ten strongly associated variants, layered H3K4Me1, H3K4Me3, and H3K27Ac chromatin immunoprecipiation (ChIP-seq), DNAse I hypersensitivity sequencing (DNase) and transcription factor ChIP-seq (TF-ChIP-Seq) data from the ENCODE project are shown (b) as displayed by the UCSC Genome Browser (lower panels).