Figure 1: Persistent antigen recognition drives heterogeneity of HCV-specific CD8+ T cells. | Nature Communications

Figure 1: Persistent antigen recognition drives heterogeneity of HCV-specific CD8+ T cells.

From: TCF1+ hepatitis C virus-specific CD8+ T cells are maintained after cessation of chronic antigen stimulation

Figure 1

(a) CD127/PD1 co-expression analysis of 24 HCV epitope-specific CD8+ T-cell populations derived from 19 chronically HCV-infected patients targeting autologous viral epitopes. Subset definition, specifically CD127+PD1+, CD127-PD1lo and CD127-PD1hi cells, is depicted in the representative flow cytometry dot plot on the left (red: HCV epitope-specific CD8+ T cells; grey: corresponding bulk CD8+ T cells of the appropriate patient). (b) Analysis of CD127/PD1 co-expression of five HCV epitope-specific CD8+ T-cell populations from five chronically HCV-infected patients that do not recognize viral antigen due to viral escape mutations. Representative dot plot on the left shows HCV epitope-specific (red) and bulk (grey) CD8+ T cells. Bar charts show the median value with interquartile range. Friedman and Dunn’s multiple comparison tests were applied for paired statistical analyses. (*P<0.05)

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