Figure 4: Memory-like and conventional memory HCV-specific CD8+ T cells differ. | Nature Communications

Figure 4: Memory-like and conventional memory HCV-specific CD8+ T cells differ.

From: TCF1+ hepatitis C virus-specific CD8+ T cells are maintained after cessation of chronic antigen stimulation

Figure 4

HCV epitope-specific CD8+ T cells from patients (n=9–10) 12 weeks after the end of DAA therapy (cHCV FU12) were compared to HCV epitope-specific CD8+ T cells from patients who spontaneously resolved HCV infection (SpR; n=6). Representative flow cytometric dot plots depict CD127/PD1 co-expression of HCV epitope-specific CD8+ T cells derived from cHCV FU12 (a) and SpR (b) (red: HCV epitope-specific CD8+ T cells, grey: corresponding bulk CD8+ T cell). Frequencies of the indicated CD127/PD1 subset (c,d), Eomeshi (e) and TCF1+ cells (f) among HCV epitope-specific CD8+ T cells present in cHCV FU12 and SpR. Bar charts show the median value with interquartile range. Statistical significance was assessed by Mann—Whitney test. (*P<0.05; ***P<0.001.)

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