Figure 7: Memory-like HCV-specific CD8+ T cells provide recall response after viral relapse. | Nature Communications

Figure 7: Memory-like HCV-specific CD8+ T cells provide recall response after viral relapse.

From: TCF1+ hepatitis C virus-specific CD8+ T cells are maintained after cessation of chronic antigen stimulation

Figure 7

Longitudinal analyses of HCV epitope-specific CD8+ T cells of one patient with HCV relapse after DAA-mediated antigen elimination. (a) Viral loads (HCV RNA) in serum samples at the indicated time-points were determined. Lower detection limit is indicated by blue dashed line. (b) Frequencies of NS31073-specific CD8+ T-cell populations at end of therapy (EOT) and after viral relapse at FU12 and FU58 are shown. (c) CD127/PD1 subset distribution and relative expression of CD39 (d), Eomeshi (e) and TCF1 (f) of NS31073-specific CD8+ T cells were assessed at the indicated time-points (red: HCV epitope-specific CD8+ T cells; grey: corresponding CD8+ T cells).

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