Table 1 Baseline patient characteristics.

From: Clonal evolution in myelodysplastic syndromes

UPN

Sex

Age

Duration of AHD (months)

AHD type

MDS subtype (FAB)

MDS subtype (WHO)

IPSS-R

Transformation to AML

Cause of death

Cytogenetic abnormalities

Follow up time (years)

Sampling moments( n)

1

F

51

7

Anaemia

RAEB

RAEB-1

High

No

NA

del5q, t(X;16)

11.2

19

2

M

62

7

Anaemia

RARS

RARS

Very low

No

TBC

NN

5.0

5

3

M

56

40

Anaemia

RARS

RARS

Very low

No

Prostate cancer

NN

7.7

6

4

M

66

43

Granulocytopenia

RAEB

RAEB-1

Low

No

NA

NN

8.1

9

5

M

64

66

Thrombocytopenia

RA

RCMD

Int

Yes

AML

+8

7.0

6

6

M

58

6

Anaemia

RARS

RCMD

Low

No

MDS/pneumonia

+21

5.3

5

7

M

67

81

Pancytopenia

RAEB

RAEB-1

Int

Yes

AML

NN

3.7

7

8

F

67

40

Anaemia, Granulocytopenia

RAEB

RAEB-1

Int

No

NA

del5q, t(1;10)

11.3

13

9

F

73

69

Anaemia

RA

RA

Low

No

Heart failure

del5q, del9q

6.6

13

10

F

57

70

Thrombocytosis

RA

RCMD

Int

No

NA

del5q, del13q

9.3

31

11

M

67

0

NA

RA

RCMD

Int

Yes

AML

NN

2.4

6

  1. AHD, antecedent haematological disease; AML, acute myeloid leukaemia; F, female; FAB, French–American–British classification system; Int, intermediate; IPSS-R, Revised International Prognostic Scoring System; M, male; NA, not applicable; NN, normal karyotype. RA, refractory anaemia; RAEB-1, refractory anaemia with excess blasts-1; RARS, refractory anaemia with ringed sideroblasts; RCMD, refractory cytopenia with multilineage dysplasia; TBC, tuberculosis; UPN, unique patient number; WHO, World Health Organization classification system.