Figure 3: PanDDA maps clearly show detail obscured by conventional maps. | Nature Communications

Figure 3: PanDDA maps clearly show detail obscured by conventional maps.

From: A multi-crystal method for extracting obscured crystallographic states from conventionally uninterpretable electron density

Figure 3

JMJD2D fragment screening data set x401 at 1.48 Å. (a,b) Conventional maps (2mFo–DFc, blue, contour as indicated; mFo–DFc, green/red, ±3σ) are dominated by the NOG co-factor analogue bound in the majority fraction of the crystal, whereas (c) the event map (blue, 2σ, BDC=0.9) and the Z-map (green/red, ±4) unambiguously reveal both ligand and associated changes in protein conformations.

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