Figure 7: CaP-rHDL-mediated efficient delivery of siRNA in C6 glioblastoma cells. | Nature Communications

Figure 7: CaP-rHDL-mediated efficient delivery of siRNA in C6 glioblastoma cells.

From: Lipoprotein-biomimetic nanostructure enables efficient targeting delivery of siRNA to Ras-activated glioblastoma cells via macropinocytosis

Figure 7

(a) Lysosome escape of FAM-siRNA (green) loaded by CaP-rHDL after incubation for 2, 4 and 8 h at the siRNA concentration of 100 nM in C6 glioblastoma cells. Lysosome was indicated by LysoTracker Red. Nucleus was stained by Hoechst33342 (blue). (b) Dissociation of FAM-siRNA (green) from its carrier CaP-rHDL after incubation for 2, 4, 8 and 12 h at the siRNA concentration of 100 nM in C6 glioblastoma cells. DiI (red) was inserted in the lipid membrane of CaP-rHDL as the fluorescent probe. Nucleus was stained by Hoechst33342 (Blue). Scale bar: 10 μm.

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