Figure 6: KDM3A/B bind to Wnt target gene promoters to erase H3K9me2 marks. | Nature Communications

Figure 6: KDM3A/B bind to Wnt target gene promoters to erase H3K9me2 marks.

From: KDM3 epigenetically controls tumorigenic potentials of human colorectal cancer stem cells through Wnt/β-catenin signalling

Figure 6

(a) The bar chat shows the distribution of distances between KDM3B or H3K9me2 peaks and TSS. (b) Average levels of KDM3B and H3K9me2 enrichment within ± 5 kb of TSS in HCT116/ABsh-1 cells were compared to HCT116/Scrsh cells. (c) Gene ontology analysis of enriched H3K9me2 target genes. The x-axis value is − log10 of binomial raw P value. (d) Average levels of KDM3B and H3K9me2 around the Wnt target genes transcription start site in HCT116/Scrsh cells were compared to HCT116/ABsh-1 cells. (e–h) Representative view of ChIP-seq results in AXIN2, DKK1, CCND1 and MYC gene by Genome Browser.

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