Figure 1: Expression of TAZ and YAP during SC development. | Nature Communications

Figure 1: Expression of TAZ and YAP during SC development.

From: A reciprocal regulatory loop between TAZ/YAP and G-protein Gαs regulates Schwann cell proliferation and myelination

Figure 1

(a) Immunofluorescence staining of TAZ (upper panels) and YAP (lower panels), SOX10 and S100β (white) in rat SCs at low and high cell densities. Scale bar, 100 μm. (b) Immunofluorescence staining of TAZ (green, upper panels) and YAP (green, lower panels) and SOX10 (red) in teased fibres from mouse P8 sciatic nerves. 4,6-Diamidino-2-phenylindole (DAPI) nuclear counterstain is shown in blue. Scale bar, 10 μm. (c) Western blot of TAZ and YAP of sciatic nerves at developmental time points as indicated (The experiment was repeated twice on 2 animals). (d) Immunofluorescence staining of TAZ (green, upper panels) and YAP (green, lower panels) and SOX10 (red) in a sciatic nerve section at P7. Scale bar, 20 μm. (e) Immunofluorescence staining of TAZ (green, upper panels) and YAP (green, lower panels) and SOX10 (red) in a sciatic nerve section at P60. Scale bar, 20 μm. (f) Percentages of cells expressing TAZ or YAP among SOX10+ SCs in wild-type mice at P7 and P60. (n=3 animals/genotype; the experiment was repeated on 3 different sections/animal).

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