Figure 9: Model by which stress fibre and cell stiffening sustain proliferation. | Nature Communications

Figure 9: Model by which stress fibre and cell stiffening sustain proliferation.

From: Actin stress fiber organization promotes cell stiffening and proliferation of pre-invasive breast cancer cells

Figure 9

Early during cellular transformation, low Src activity promotes stress fibre assembly and upregulates EVL. Organization of these fibres by EVL leads to cell stiffening. Both EVL and myosin II-dependent cell stiffening potentiates ERK activity, sustains cell proliferation, as well as enhance Src activation. Later during transformation, higher Src activity, in addition to a reduction in EVL levels, would disassemble stress fibres to facilitate cell migration.

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