Figure 1: EpoR−/−TgEpoRE mice (Tg) develop obesity.
(a,b) Body weight versus age of WT-mice (solid line) and Tg-mice (dashed line) are indicated for female (a) (n=13) and male (b) (n=15) mice. (c–e) Measurements of body weight (c), lean mass (d) and fat mass (e) of Tg-mice (solid bar) and age-/sex-matched WT-mice (open bar) at 8 months of age are indicated (male: Tg (n=4), WT (n=4); female: Tg (n=9), WT (n=6)). (f) Representative whole-body X-ray CT scan of 8-month-old female mice shows fat tissue (white) distribution by density for coronal (upper) views (visceral and subcutaneous white fat) and sagittal (lower) views (brown fat in the dorsal neck), scale bar=20 mm. (g,h) Volume analyses for brown fat (BF), visceral fat (VF) and subcutaneous fat (SF) were determined for female (g) (n=9) and male (h) (n=4) mice. (i,j) Body weight of EpoR heterozygous EpoR+/−-mice (blue) and EpoR+/−TgEpoRE-mice (green) was compared with age-/sex-matched WT-mice (red) (female: i and male: j; n=14 in each group). Error bars indicate s.e.m. and significance is indicated by *P<0.05 and **P<0.01 determined by Student's t-test.
