Figure 4: Interaction between VPGSGW and HK68/H3 HA1. | Nature Communications

Figure 4: Interaction between VPGSGW and HK68/H3 HA1.

From: In vitro evolution of an influenza broadly neutralizing antibody is modulated by hemagglutinin receptor specificity

Figure 4

(a) The crystal structure of VPGSGW in complex with HA1 exhibits a similar conformation to that of C05 WT in complex with HA1 (PDB: 4FP8)21. (b) There are two VPGSGW-HA1 complexes in the asymmetric unit of the crystal structure. The orientations of the serine at 100d differ between those two complexes. Intramolecular hydrogen bonds are shown for the two different conformations of CDR H3 of VPGSGW. (c) Interaction of the HA RBS (grey) with CDR H3 (pink) is shown. Hydrogen bonds are represented by green dashed lines. Water molecules are represented by red spheres. A putative sodium ion is represented by the purple sphere. For clarity, only G100c, S100d, G100e, and W100f on the CDR H3 of VPGSGW are displayed.

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