Figure 5: ACF7 cKO mice are more susceptible to DSS-induced colitis. | Nature Communications

Figure 5: ACF7 cKO mice are more susceptible to DSS-induced colitis.

From: ACF7 regulates inflammatory colitis and intestinal wound response by orchestrating tight junction dynamics

Figure 5

(a) Kaplan–Meier survival curve of DSS treatment in ACF7 cKO mice and WT littermates (n=6 animals, **P<0.01, log-rank test). (b–e) To quantitatively evaluate DSS-induced colitis, we examined body weight loss (b), disease activity index (c), faecal blood (d) and diarrhoea (e) in ACF7 cKO animals and WT littermates (mean±s.e.m., n=6 per time point per group, *P<0.05, **P<0.01; Student’s t-test). Note significantly enhanced disease development in cKO group. (f,g) The colon weight and length of WT and ACF7 cKO mice were measured and quantified (means±s.e.m., n=6 animals, data with different superscript letters P<0.05, one-way ANOVA). (h) Representative H/E staining images of WT and ACF7 cKO colon at the end of DSS treatment. Scale bar, 200 μm.

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