Figure 3: Biological inference for the psoriasis loci. | Nature Communications

Figure 3: Biological inference for the psoriasis loci.

From: Large scale meta-analysis characterizes genetic architecture for common psoriasis associated variants

Figure 3

(a) Enriched functions (nodes) among the associated loci identified using MEAGA. For illustration purposes, only functions with at least four genes overlapping with other enriched functions are shown (the full list of enriched functions/pathways is shown in Supplementary Table 6). The size of the nodes and the width of the edges correlate with the number of overlapped disease-loci and the number of shared disease-loci, respectively. Nodes with dark blue colour represents higher numbers of overlapped loci while lighter colour represents lower numbers of overlapped loci. The functional annotations for the nodes are presented in Supplementary Fig. 8. (b) The observed-to-expected ratio of the number of regulatory-element overlapped loci versus the enrichment p value. Immune cells are highlighted in blue.

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