Table 1 List of proteins with altered stability.

From: pSILAC mass spectrometry reveals ZFP91 as IMiD-dependent substrate of the CRL4CRBN ubiquitin ligase

Significance B analysis single time point

Limma analysis across all samples

Gene ID

LogFC

P value

LogFC

P value

ΔHalf-life

Down

 CSNK1A1

0.62

2.2 × 10−85

0.72

7.6 × 10−5

Hit

 CA2

0.29

4.1 × 10−15

0.08

0.07

No hit

 LASP1

0.13

5.3 × 10−10

0.05

0.51

No hit

 ZFP91

0.34

7.9 × 10−8

0.57

0.0004

No hit*

Up

 NAA30

−0.40

3.0 × 10−22

−0.18

0.39

No hit

 NCSTN

−0.39

2.3 × 10−21

−0.32

0.07

No hit

 POMP

−0.32

3.6 × 10−14

−0.12

0.34

No hit

 GNL3L

−0.29

3.0 × 10−12

−0.41

0.06

No hit

  1. Log2 fold changes are shown together with their respective P values. For half-life analysis, we qualitatively designated a protein a ‘hit’ or ‘no hit’.
  2. *ZFP91 was dropped from the half-life analysis for a missing value in one time point and is therefore designated ‘no hit’.