Figure 4: BIG3 overexpression and PHB2 dephosphorylation status are strongly associated with poor prognosis.
From: A-kinase anchoring protein BIG3 coordinates oestrogen signalling in breast cancer cells
(a,b) Immunohistochemical staining (upper) and Kaplan–Meier analysis (lower) of survival associated with BIG3 protein (a) and nuclear PHB2 phosphorylation at S39 (b) in representative ERα-positive breast cancer specimens. (c) BIG3 protein expression, showing an independent prognostic significance in the multivariate Cox regression analysis. (d) Reverse correlation of BIG3 expression with PHB2 phosphorylation status at S39 according to Fisher’s exact test. For overall survival analysis, the log-rank (Mantel-Cox) test was used to determine the statistical difference between stratified groups.
