Figure 5: Mutations in melanoma tissue samples and cell lines. | Nature Communications

Figure 5: Mutations in melanoma tissue samples and cell lines.

From: Acquired IFNγ resistance impairs anti-tumor immunity and gives rise to T-cell-resistant melanoma lesions

Figure 5

(a) Genetic alterations (homozygous deletions, single-nucleotide variants [SNV], small insertions and deletions [Indel]) in components of the type II IFN signalling pathway in TCGA melanoma samples (n=287, accessed 31/12/2016). (b) Mutations in JAK1, JAK2 and BRAF in the TCGA melanoma dataset stratified by tissue origin (primary tumours vs metastases). y axis, indicates expression of corresponding mRNA. Each circle represents a sample, samples harbouring SNV or Indels are shown in red (n=287, accessed 30/12/2016). (c–e) Recurrent mutations of type II IFN signalling pathway genes in published datasets15,19,20. (f) SNP array data from 59 melanoma cell lines21 show LOH at the JAK1 (Chr. 1p31.3) and JAK2 (Chr. 9p24.1) locus.

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