Figure 3: Distinct classes of structural and regulatory interactions occur at different distance ranges.

(a) Relative enrichments of significant HiC-DC interactions (FDR < 1%) for the Rao et al.¹¹ GM12878 data as annotated by epigenetic signals, as a function of genomic distance. For each 10 kb band, enrichment of interactions with each specific annotation were computed relative to the background prevalence of this annotation (by Fisher’s exact test), and then the enrichment P values for each annotation over 100 kb distance subranges were compared to all other annotations (Methods section). (b) Relative enrichments of significant HiC-DC interactions (FDR<1%) for the Rao et al.¹¹ data as annotated by genomic location (promoter, gene body, or distal intergenic), as a function of genomic distance. Enrichment of interactions for each 10 kb band were computed as in a, then the enrichment P values for each annotation over 50 kb distance subranges were compared as in a.