Figure 7: Control of type-one errors for assessing a genotype by sex interaction in the presence of a genotype effect for continuous traits.

A simulation study, to assess the stage 2 type-one error rate, where a genotype effect affecting both sexes has been added to the knockout mice as signal (as a function of standard deviation for four levels: 0.5, 1, 1.5, 2). (a) The average stage 2 type-one error rate as a function of the significance threshold. Only one level can be seen as the lines overlay each over. (b) The stage 2 type-one error rate at the trait level for the 0.05 significance threshold as a function of the signal added. Shown is a boxplot giving a five point summary (minimum, first quantile, mean, third quantile and maximum).